Early and late Toxicity in Locally Advanced Carcinoma of Cervix (Stage‐IIB to IIIB) During Using High Dose Rate (HDR) Brachytherapy (4#x7Gy) in Between External Beam Radiotherapy (46Gy/23#)

Abstract

To observe the early and late toxicity in locally advanced carcinoma of cervix (STAGE‐IIB’ to IIIB) during using high dose rate (HDR) Brachytherapy in between External Beam Radiotherapy. The study was performed in the Department of Radiotherapy, Regional Cancer Institute, DR. B.R.A.M. Hospital, Raipur(C.G.) Total 50 patients of cervical cancer up to IIIB who were diagnosed as cervical cancer are taken in the study. Acute toxicities were noted, 0.28% patient developed grade I skin toxicities , 10.85% patients developed grade I and II gastrointestinal toxicities (nausea ,vomiting , abdominal pain, diarrhoea), 9.43% patients developed grade I and II haematological toxicities(anemia , neutropenia ) and 32% patients developed grade I and II genitourinary toxicities(burning micturition, increased frequency of urination) according to R.T.O.G. toxicity criteria. Late toxicities were noted, 11% patients developed grade I and IIhaematological toxicities (anemia and neutropenia), 11% patients developed grade I and II gastrointestinal toxicities (abdominal pain, anorhexia, nausea, vomiting, diarrhoea, pain during defecation and rectal bleeding) and 9% patients developed grade I and II genitourinary toxicities (dysuria and haematuria) according to R.T.O.G. toxicity criteria. In this study, early toxicities such as skin toxicities, diarrhoea, vomiting, burning micturition, pain during defecation, anaemia, neutropenia occurred which were well manageable.